›› 2011, Vol. 23 ›› Issue (3): 166-170.doi: 10.3969/j.issn.1004-616x.2011.03.002

• 论著 • Previous Articles     Next Articles

Identification of the cancer chemoprevention component in fungus plant extract AMH

HE Xiao-qiong，LI Ning-shi，LI Feng，ZHAO Yan，WU Jing-cong，ZHU Qi-ying，YUAN Yin   

  1. School of Public Health, Kunming Medical College, Kunming 650500, Yunnan, China
  • Received:2011-02-24 Revised:2011-03-29 Online:2011-05-30 Published:2011-05-30
  • Contact: HE Xiao-qiong

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Abstract: To identify the cancer chemoprevention component in fungus plant extract AMH， which has been proved having antimutagenic and cancer chemopreventive effect. Present study may provide scientific data for the further separation of bioactive agents and for anticancer drug development. METHODS：The benzo(a)pyrene-induced oncogenesis assay was used to evaluate the cancer chemopreventive effect of the 5 components separated from fungus extract AMH. RESULTS：Benzo(a)pyrene could induce organ cancers and lung adenoma in Kunming mice. Compared with the control group，components A， B，C and E could promote the occurrence of lung adenoma (P<0.05). Components B and E could inhibit the occurrence of cancers induced by benzo(a)pyrene (P<0.05) whilst component D could inhibit both cancers and lung adenoma induced by benzo(a)pyrene (P<0.01). Component D was the bioactive component which had cancer chemopreventive effect. CONCLUSION： Component D had cancer chemopreventive effect. It was the functional component worthy of further identification of the bioactive agents.

Key words: fungus extract AMH, tumor, benzo(a)pyrene, lung adenoma